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materials and  reagents  that ensure the   research that results in scientific publica-  5. Startups and Entrepreneurship
 maintenance of a favorable environment   tions and patents in Health Sciences has
 for obtaining of the final biological prod-  been decreasing in the last 10 years, in   Brazil is a highly entrepreneurial country.   by 41.9% between 2011 and 2014, show-
 uct. Thus, considering the research time   some areas such as Antibiotics/Biofilm and   According  to  the  Global  Entrepreneurship   ing that there is still room for biotechnology
 required to obtain a biological medicine   Anticancer there is still a large proportion   Monitor Brazil, in 2016, for every 100 inhab-  growth in the country. Furthermore, in the
 that has been proven to be safe and ef-  of  scientific  publications  when  compared   itants, 36 were entrepreneurs, a rate higher   2018 edition of BioBr magazine, prominent
 fective, it is expected that the Brazilian   to the patents (Figure 5). Thus, this may   than many other Latin American countries   companies and organizations shared their
 patent  system  will  be  dynamic  and  fast   be one of the greatest national challenges   and even some “developed” countries. This   views on the biotechnology landscape in Bra-
 in relation to the area of  Biotechnology.  for greater development and use of knowl-  is reflected in the biotechnology sector, as   zil and examples of their innovation activities.

 Also, although the proportion between   edge for the benefit of society in Brazil.  there are many startups being created with   Today’s entrepreneurship is increasingly relat-
                   a focus on projects in this area.        ed to technological innovation, and biotech-
                     According to a mapping by the Brazilian   nology is nothing more than innovation.
 80000             Startup Association (ABStartups), there are   According to studies by CEBRAP, de-
                   more than 4.2 million startups in Brazil, but   veloped in partnership with BrBiotec and
 70000
                   it is still difficult to estimate how many are   APEX do Brasil, in 2011 Brazil had 237
                   working  with  biotechnology.  To  alleviate
                                                            biotechnology companies, 63% of which
 Publications (2010-2022)  50000  and Apex-Brasil are working on mapping   78% of these companies depend on public
 60000
                   this lack of data, Biominas Brasil, Abiquifi
                                                            were created in the last decade. However,
                   startups in Brazil that work with pharma-
                                                            funding to perform their functions. The most
 40000
                                                            prominent  area  of  activity  is  human  health
                   ceutical ingredients, chemical and biologi-

 30000
                   cal compounds, medical equipment, digital
                                                            research (about 40%), followed by animal
 20000
                   health,  human  and  animal  pharmaceuti-
                                                            ronment and bioenergy together cover 25%
                   cals, animal nutrition and biotechnology   health (14%). The areas of agriculture, envi-
 10000
                   in general. It will also map the country’s   of Brazilian biotechnology companies. Of all
 0                 main innovation clusters in these areas; the   these entities, 80% are micro and small com-
 Antiparasitic/ Pesticides
 Antifungal/Pesticides
 Antibiotics/Biofilm  Anticancer  Antiviral Neuroprotective  Analgesic  Antiihypertensive  type of solutions being researched; and the   panies that suffer from a lack of investment,
                   products already in the prototype phase.
                                                            unavailability of inputs, excessive bureaucra-
                                                            cy, and inexperience to complete the devel-
                     A survey conducted by Biominas (2017)
                   revealed the general profile of Brazilian bio-
                   technology  companies.  Most  (about  60%)   opment of their products.
                                                               Normally in the creation of companies
  Publications       Patents
                   are small, with up to 10 employees, and   (Startups for example), although there are re-
                   young, under 10 years old. Almost 70% of   sources available for the initial research phase,
 Source: Own Elaboration (2022)
                   the companies have already carried out some   there is usually a lack of product testing and
                   type of international cooperation and all re-  the separation of incubators. The incubators
 Figure 5. Publications and patents re-  ywords anywhere in the text “biotech-  spondents showed interest in carrying out fu-  are normally maintained with a contribu-
 gistered with Google Academic and   nology”, “marine” and switching betwe-  ture cooperation activities. Large companies   tion of federal resources from the Financier
 Google Patents, respectively, between   en “anti-parasitic”, “antifungal”, “an-  are also seeking innovation through biotech-  of Studies and Projects (Finep - Financiado-
 2010 and 2022. The search criteria were:   tihypertensive”,  “anti-inflammatory”,
 articles  or  patents  of  any  nature  and   “antiviral”, “neuroprotective”, “analge-  nology projects. According to the Brazil Inno-  ra de Estudos e Projetos), and the incubated
 language, except revisions, with all ke-  sic”, “antibiotic” and “anticancer”.  vation Survey (PINTEC), the number of inno-  companies depend on these resources both
                   vative companies using biotechnology grew   to develop  their products  and  to invest  in

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