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materials and  reagents  that ensure the   research that results in scientific publica-                           5. Startups and Entrepreneurship
               maintenance of a favorable environment   tions and patents in Health Sciences has
               for obtaining of the final biological prod-  been decreasing in the last 10 years, in                                Brazil is a highly entrepreneurial country.   by 41.9% between 2011 and 2014, show-
               uct. Thus, considering the research time   some areas such as Antibiotics/Biofilm and                             According  to  the  Global  Entrepreneurship   ing that there is still room for biotechnology
               required to obtain a biological medicine   Anticancer there is still a large proportion                           Monitor Brazil, in 2016, for every 100 inhab-  growth in the country. Furthermore, in the
               that has been proven to be safe and ef-  of  scientific  publications  when  compared                             itants, 36 were entrepreneurs, a rate higher   2018 edition of BioBr magazine, prominent
               fective, it is expected that the Brazilian   to the patents (Figure 5). Thus, this may                            than many other Latin American countries   companies and organizations shared their
               patent  system  will  be  dynamic  and  fast   be one of the greatest national challenges                         and even some “developed” countries. This   views on the biotechnology landscape in Bra-
               in relation to the area of  Biotechnology.  for greater development and use of knowl-                             is reflected in the biotechnology sector, as   zil and examples of their innovation activities.

                 Also, although the proportion between   edge for the benefit of society in Brazil.                              there are many startups being created with   Today’s entrepreneurship is increasingly relat-
                                                                                                                                 a focus on projects in this area.        ed to technological innovation, and biotech-
                                                                                                                                    According to a mapping by the Brazilian   nology is nothing more than innovation.
                    80000                                                                                                        Startup Association (ABStartups), there are   According to studies by CEBRAP, de-
                                                                                                                                 more than 4.2 million startups in Brazil, but   veloped in partnership with BrBiotec and
                    70000
                                                                                                                                 it is still difficult to estimate how many are   APEX do Brasil, in 2011 Brazil had 237
                                                                                                                                 working  with  biotechnology.  To  alleviate
                                                                                                                                                                          biotechnology companies, 63% of which
                  Publications (2010-2022)  50000                                                                                and Apex-Brasil are working on mapping   78% of these companies depend on public
                    60000
                                                                                                                                 this lack of data, Biominas Brasil, Abiquifi
                                                                                                                                                                          were created in the last decade. However,
                                                                                                                                 startups in Brazil that work with pharma-
                                                                                                                                                                          funding to perform their functions. The most
                    40000
                                                                                                                                                                          prominent  area  of  activity  is  human  health
                                                                                                                                 ceutical ingredients, chemical and biologi-

                    30000
                                                                                                                                 cal compounds, medical equipment, digital
                                                                                                                                                                          research (about 40%), followed by animal
                    20000
                                                                                                                                 health,  human  and  animal  pharmaceuti-
                                                                                                                                                                          ronment and bioenergy together cover 25%
                                                                                                                                 cals, animal nutrition and biotechnology   health (14%). The areas of agriculture, envi-
                    10000
                                                                                                                                 in general. It will also map the country’s   of Brazilian biotechnology companies. Of all
                       0                                                                                                         main innovation clusters in these areas; the   these entities, 80% are micro and small com-
                                                                 Antiparasitic/ Pesticides
                                  Antifungal/Pesticides
                   Antibiotics/Biofilm  Anticancer  Antiviral Neuroprotective  Analgesic  Antiihypertensive                      type of solutions being researched; and the   panies that suffer from a lack of investment,
                                                                                                                                 products already in the prototype phase.
                                                                                                                                                                          unavailability of inputs, excessive bureaucra-
                                                                                                                                                                          cy, and inexperience to complete the devel-
                                                                                                                                    A survey conducted by Biominas (2017)
                                                                                                                                 revealed the general profile of Brazilian bio-
                                                                                                                                 technology  companies.  Most  (about  60%)   opment of their products.
                                                                                                                                                                             Normally in the creation of companies
                                             Publications       Patents
                                                                                                                                 are small, with up to 10 employees, and   (Startups for example), although there are re-
                                                                                                                                 young, under 10 years old. Almost 70% of   sources available for the initial research phase,
                                                                      Source: Own Elaboration (2022)
                                                                                                                                 the companies have already carried out some   there is usually a lack of product testing and
                                                                                                                                 type of international cooperation and all re-  the separation of incubators. The incubators
                 Figure 5. Publications and patents re-  ywords anywhere in the text “biotech-                                   spondents showed interest in carrying out fu-  are normally maintained with a contribu-
                 gistered with Google Academic and      nology”, “marine” and switching betwe-                                   ture cooperation activities. Large companies   tion of federal resources from the Financier
                 Google Patents, respectively, between   en “anti-parasitic”, “antifungal”, “an-                                 are also seeking innovation through biotech-  of Studies and Projects (Finep - Financiado-
                 2010 and 2022. The search criteria were:   tihypertensive”,  “anti-inflammatory”,
                 articles  or  patents  of  any  nature  and   “antiviral”, “neuroprotective”, “analge-                          nology projects. According to the Brazil Inno-  ra de Estudos e Projetos), and the incubated
                 language, except revisions, with all ke-  sic”, “antibiotic” and “anticancer”.                                  vation Survey (PINTEC), the number of inno-  companies depend on these resources both
                                                                                                                                 vative companies using biotechnology grew   to develop  their products  and  to invest  in

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