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2. Impacts of marine bioprospecting on Brazilian and world society
 Figure 2. The relevance of the Amazônia Azul (Blue Amazon)
 in the context of Marine Biotechnology  The impact of marine bioprospecting   work was published there were only two
                   on  society  is  evidenced by the  growing   pharmaceuticals based on marine natural
                   number of studies involving marine bio-  products approved for clinical use against
                   technology and the large areas of Health,   cancer. However, in the last decade that
                   Energy, Materials and Defense, consolidat-  number has risen to 12, which far exceeds
                   ing its great current and future potential   the predictions originally made. In Brazil,
 0 S               for Brazilian and global society (Figure 3).  there are two Brazilian innovations based
 0
                     In 2010, Erwin and colleagues demon-   on natural products approved for clinical
                   strated a monetary estimate for the phar-  use, Acheflan® as an anti-inflammatory,
 BLUE AMAZON
                   maceutical value  of  marine biodiversity   obtained from Cordia verbenacea, known
 EEZ = 3,540,000 KM²  from the potential for drug discovery to   as baleeira weed or  maria-milagrosa, by
 Extension = 960,000 KM²  treat cancer. Estimating up to 600,000   Aché Laboratories, and from Helleva® for
 TOTAL AREA 4.5    new chemical substances, 90% of which    erectile dysfunction, made up of lodenafil
                   are awaiting their discovery, they suggest-  carbonate,  a  synthetic  substance  devel-
 MILLION KM²
 20 S              ed that this study could result in the devel-  oped by Cristália Produtos Químicos Far-
 0
                   opment of more than 200 new anticancer   macêuticos Ltda.
                   pharmaceuticals, which amounted to be-     Specifically in the health area, new ef-
                   tween US$563 billion and US$5.69 tril-   fective pharmaceuticals of marine origin
                   lion. It is noteworthy that at the time this   are being discovered and tested all the time



                                      Desenvolvimento da Biotecnologia Marinha
                                      Development of Marine Biotechnology
 40 S
 0
 070 W                            070 W                            030 W
 0
 0
 0
                           90000
                           90000
                           80000
 Source: Own Elaboration (2022)  80000
                           70000
                           70000
                           60000
 recognized biodiversity of species elevate  microbiologists,  biologists,  doctors,  law-  Publications  (2010-2022)  60000
                           50000
                           50000
 marine biotechnology to the level of a  yers, businessmen, economists, etc.  Publicações (2010-2022)  40000
                           40000
 strategic area in the National Science and   The purpose of the chapter is to eval-  30000
                           30000
 Technology Plan and in the Defense White  uate the  fundamentals of biotechnology,   20000
                           20000
 Book (MD, 2012; PNCT, 2000) (Figure 2).  with emphasis on marine bioprospecting   10000
                           10000
 In the present chapter, biotechnology is  and the production of derived pharma-  0 o
                                    Defesa
                                                 Materiais
                                                                  Energy
                                                                                Health
 defined as the activity based on multidis-  ceuticals, reviewing the impacts on society,     Defense       Material   Energia  Saúde
 ciplinary knowledge, which uses biological  the economic sectors involved in Brazil, the
 agents to make useful products or solve  guidelines for the full development of the   Figure  3.  Publications  registered  with   sions, with all keywords anywhere in the
                                                            article “biotechnology”, “marine” and
                     Google Scholar between 2010 and 2022.
 problems. This definition is broad enough  Blue Economy in the country and, finally,   The search criteria were: articles of any   changing between “defense”, “mate-
 to encompass activities as varied as engi-  how biotechnology is applied in various   nature  and language,  except for  revi-  rial”, “energy” and “health”
 neers, chemists, agronomists, veterinarians,  productive sectors of society.  Source: Own Elaboration (2022)
 484   BLUE ECONOMY                                                         Development of Marine Biotechnology 485
 484   BLUE ECONOMY
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