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2. Impacts of marine bioprospecting on Brazilian and world society
                           Figure 2. The relevance of the Amazônia Azul (Blue Amazon)
                                     in the context of Marine Biotechnology                                                         The impact of marine bioprospecting   work was published there were only two
                                                                                                                                 on  society  is  evidenced by the  growing   pharmaceuticals based on marine natural
                                                                                                                                 number of studies involving marine bio-  products approved for clinical use against
                                                                                                                                 technology and the large areas of Health,   cancer. However, in the last decade that
                                                                                                                                 Energy, Materials and Defense, consolidat-  number has risen to 12, which far exceeds
                                                                                                                                 ing its great current and future potential   the predictions originally made. In Brazil,
                 0 S                                                                                                             for Brazilian and global society (Figure 3).  there are two Brazilian innovations based
                  0
                                                                                                                                    In 2010, Erwin and colleagues demon-  on natural products approved for clinical
                                                                                                                                 strated a monetary estimate for the phar-  use, Acheflan® as an anti-inflammatory,
                                         BLUE AMAZON
                                                                                                                                 maceutical value  of  marine biodiversity   obtained from Cordia verbenacea, known
                                       EEZ = 3,540,000 KM²                                                                       from the potential for drug discovery to   as baleeira weed or  maria-milagrosa, by
                                     Extension = 960,000 KM²                                                                     treat cancer. Estimating up to 600,000   Aché Laboratories, and from Helleva® for
                                         TOTAL AREA 4.5                                                                          new chemical substances, 90% of which    erectile dysfunction, made up of lodenafil
                                                                                                                                 are awaiting their discovery, they suggest-  carbonate,  a  synthetic  substance  devel-
                                          MILLION KM²
                20 S                                                                                                             ed that this study could result in the devel-  oped by Cristália Produtos Químicos Far-
                  0
                                                                                                                                 opment of more than 200 new anticancer   macêuticos Ltda.
                                                                                                                                 pharmaceuticals, which amounted to be-      Specifically in the health area, new ef-
                                                                                                                                 tween US$563 billion and US$5.69 tril-   fective pharmaceuticals of marine origin
                                                                                                                                 lion. It is noteworthy that at the time this   are being discovered and tested all the time



                                                                                                                                                     Desenvolvimento da Biotecnologia Marinha
                                                                                                                                                     Development of Marine Biotechnology
                40 S
                  0
                        070 W                            070 W                            030 W
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                           0
                                                0
                                                                                                                                         90000
                                                                                                                                         90000
                                                                                                                                         80000
                                                                 Source: Own Elaboration (2022)                                          80000
                                                                                                                                         70000
                                                                                                                                         70000
                                                                                                                                         60000
               recognized biodiversity of species elevate  microbiologists,  biologists,  doctors,  law-                               Publications  (2010-2022)  60000
                                                                                                                                         50000
                                                                                                                                         50000
               marine biotechnology to the level of a  yers, businessmen, economists, etc.                                               Publicações (2010-2022)  40000
                                                                                                                                         40000
               strategic area in the National Science and   The purpose of the chapter is to eval-                                       30000
                                                                                                                                         30000
               Technology Plan and in the Defense White  uate the  fundamentals of biotechnology,                                        20000
                                                                                                                                         20000
               Book (MD, 2012; PNCT, 2000) (Figure 2).  with emphasis on marine bioprospecting                                           10000
                                                                                                                                         10000
                  In the present chapter, biotechnology is  and the production of derived pharma-                                           0 o
                                                                                                                                                   Defesa
                                                                                                                                                                Materiais
                                                                                                                                                                                               Health
                                                                                                                                                                                 Energy
               defined as the activity based on multidis-  ceuticals, reviewing the impacts on society,                                             Defense         Material   Energia       Saúde
               ciplinary knowledge, which uses biological  the economic sectors involved in Brazil, the
               agents to make useful products or solve  guidelines for the full development of the                                 Figure  3.  Publications  registered  with   sions, with all keywords anywhere in the
                                                                                                                                   Google Scholar between 2010 and 2022.
                                                                                                                                                                          article “biotechnology”, “marine” and
               problems. This definition is broad enough  Blue Economy in the country and, finally,                                The search criteria were: articles of any   changing between “defense”, “mate-
               to encompass activities as varied as engi-  how biotechnology is applied in various                                 nature  and language,  except for  revi-  rial”, “energy” and “health”
               neers, chemists, agronomists, veterinarians,  productive sectors of society.                                                                                            Source: Own Elaboration (2022)
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